Browsing Publications - Cancer Center by Issue Date
Now showing items 1-15 of 15
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Misconceptions about breast lumps and delayed medical presentation in urban breast cancer patients.
(American Association for Cancer Research, 2010-03)BACKGROUND: Despite current recommendations for women to be screened for breast cancer with mammography every one to two years, less than half of all newly diagnosed breast cancers are initially detected through screening ... -
Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma
(BioMed Central, 2010-07-09)Background: Lymph node metastasis is a critical event in the progression of tongue squamous cell carcinoma (TSCC). The identification of biomarkers associated with the metastatic process would provide critical prognostic ... -
Steroid receptor coactivator 1 deficiency increases MMTV-neu mediated tumor latency and differentiation specific gene expression, decreases metastasis, and inhibits response to PPAR ligands
(BioMed Central, 2010-11-16)Background: The peroxisome proliferator activated receptor (PPAR) subgroup of the nuclear hormone receptor superfamily is activated by a variety of natural and synthetic ligands. PPARs can heterodimerize with retinoid X ... -
Carnosol: A Promising Anti-Cancer and Anti-Inflammatory Agent
(Elsevier, 2011-06-01)The Mediterranean diet and more specifically certain meats, fruits, vegetables, and olive oil found in certain parts of the Mediterranean region have been associated with a decreased cardiovascular and diabetes risk. More ... -
Identification of ChIP-seq mapped targets of HP1β due to bombesin/GRP receptor activation
(BioMed Central, 2011-08)Epithelial cells lining the adult colon do not normally express gastrin-releasing peptide (GRP) or its receptor (GRPR). In contrast, GRP/GRPR can be aberrantly expressed in human colorectal cancer (CRC) including Caco- 2 ... -
Bioinformatic resources of microRNA sequences, gene targets, and genetic variation
(Frontiers Research Foundation, 2012)Variation in quantitative gene expression has been observed in natural populations and associated with various complex traits/phenotypes such as risks for common diseases and drug response. MicroRNAs (miRNAs), a family ... -
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-Cadherin in vitro and in mice
(Oxford University Press, 2012-02)Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in ... -
Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks
(Public Library of Science, 2012-04)Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular domains, each with distinct ligand preferences. Although ITSNs were initially implicated in the regulation of endocytosis, subsequent ... -
A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer
(Public Library of Science, 2012-09)Objective: Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with a poor prognosis. Methylation levels of genomic repeats such as LINE-1 elements have been recognized ... -
Transcriptional Regulation of the Ufm1 Conjugation System in Response to Disturbance of the Endoplasmic Reticulum Homeostasis and Inhibition of Vesicle Trafficking
(Public Library of Science, 2012-11)Homeostasis of the endoplasmic reticulum (ER) is essential for normal cellular functions. Disturbance of this homeostasis causes ER stress and activates the Unfolded Protein Response (UPR). The Ufm1 conjugation system is ... -
Breakthroughs in genomics data integration for predicting clinical outcome
(Elsevier, 2012-12) -
Quantitative FRET Imaging to Visualize the Invasiveness of Live Breast Cancer Cells
(Public Library of Science, 2013-03)Matrix metalloproteinases (MMPs) remodel tumor microenvironment and promote cancer metastasis. Among the MMP family proteases, the proteolytic activity of the pro-tumorigenic and pro-metastatic membrane-type 1 ... -
Selective Modulation of Endoplasmic Reticulum Stress Markers in Prostate Cancer Cells by a Standardized Mangosteen Fruit Extract
(PLOS ONE, 2013-12-25)The increased proliferation of cancer cells is directly dependent on the increased activity of the endoplasmic reticulum (ER) machinery which is responsible for protein folding, assembly, and transport. In fact, it is so ... -
MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis
(American Society of Hematology, 2014)From 2007 to 2011, 66 patients with primary myelofibrosis or myelofibrosis (MF) preceded by essential thrombocythemia or polycythemia vera were enrolled into a prospective phase 2 clinical trial of reduced-intensity ... -
Nitric oxide donor [Ru(terpy)(bdq)NO]3+ induces uncoupling and phosphorylation of endothelial nitric oxide synthase promoting ROS and peroxynitrite production
(Elsevier, 2017-11-01)TERPY is a nitric oxide (NO) donor that promotes relaxation of the mesenteric artery and aorta in rats. We sought to investigate whether it acts as both an NO donor and endothelial NO synthase (eNOS) activator, as shown ...