Now showing items 1-6 of 6
Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks
(Public Library of Science, 2012-04)
Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular domains, each with distinct ligand preferences. Although ITSNs were initially implicated in the regulation of endocytosis, subsequent ...
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-Cadherin in vitro and in mice
(Oxford University Press, 2012-02)
Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in ...
Transcriptional Regulation of the Ufm1 Conjugation System in Response to Disturbance of the Endoplasmic Reticulum Homeostasis and Inhibition of Vesicle Trafficking
(Public Library of Science, 2012-11)
Homeostasis of the endoplasmic reticulum (ER) is essential for normal cellular functions. Disturbance of this homeostasis causes ER stress and activates the Unfolded Protein Response (UPR). The Ufm1 conjugation system is ...
Bioinformatic resources of microRNA sequences, gene targets, and genetic variation
(Frontiers Research Foundation, 2012)
Variation in quantitative gene expression has been observed in natural populations and associated with various complex traits/phenotypes such as risks for common diseases and drug response. MicroRNAs (miRNAs), a family ...
A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer
(Public Library of Science, 2012-09)
Objective: Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with a poor prognosis. Methylation levels of genomic repeats such as LINE-1 elements have been recognized ...
Breakthroughs in genomics data integration for predicting clinical outcome