Now showing items 1-3 of 3
IL-4 Regulates Chemokine CCL26 in Keratinocytes through the Jak1, 2/Stat6 Signal Transduction Pathway: Implication for Atopic Dermatitis
Atopic dermatitis (AD), a chronic, pruritic, inflammatory skin disease, is histopathologically characterized by epidermal hyperplasia and infiltration of T cells, mast cells, and eosinophils. Clinical study and basic ...
IL-4 up-regulates epidermal chemotactic, angiogenic, and pro-inflammatory genes and down-regulates antimicrobial genes in vivo and in vitro: relevant in the pathogenesis of atopic dermatitis
Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Although the pathogenesis of AD is not fully understood, we and others have shown that IL-4 plays a key role. In this study we aimed to identify ...
IL-4 dysregulates microRNAs involved in inflammation, angiogenesis and apoptosis in epidermal keratinocytes
IL-4 plays an important role in atopic dermatitis (AD) pathogenesis by dysregulating many key factors at the transcriptional level. In this study, using microRNA array technique and IL-4 transgenic mice, we demonstrated ...