Browsing Publications - Pharmaceutical Biotechnology by Title

Now showing items 13-18 of 18

    • Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI). 

      Mehboob, S.; Song, J.; Hevener, K.E.; Su, P-C.; Boci, T.; Brubaker, L.; Truong, L. (Elsevier Inc., 2015-03-15)
      Francisella tularensis, the causative agent of tularemia, presents a significant biological threat and is a Category A priority pathogen due to its potential for weaponization. The bacterial FASII pathway is a viable ...

    • Structure of dihydroorotase from Bacillus anthracis at 2.6 A resolution 

      Mehboob, Shahila; Mulhearn, Debbie C.; Truong, Kent; Johnson, Michael E.; Santarsiero, Bernard D. (International Union of Crystallography, 2010-11)
      Dihydroorotase (EC 3.5.2.3) catalyzes the reversible cyclization of N-carbamoyl-l-aspartate to l-dihydroorotate in the third step of the pyrimidine-biosynthesis pathway in Bacillus anthracis. A comparison is made between ...

    • Structure of dihydroorotase from Bacillus anthracis at 2.6 A resolution 

      Mehboob, Shahila; Mulhearn, Debbie C.; Truong, Kent; Johnson, Michael E.; Santarsiero, Bernard D. (International Union of Crystallography, 2010-11)
      Dihydroorotase (EC 3.5.2.3) catalyzes the reversible cyclization of N-carbamoyl-l-aspartate to l-dihydroorotate in the third step of the pyrimidine-biosynthesis pathway in Bacillus anthracis. A comparison is made between ...

    • The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics 

      Auerbach, Tamar; Mermershtain, Inbal; Davidovich, Chen; Bashan, Anat; Belousoff, Matthew; Wekselman, Itai; Zimmerman, Ella; Xiong, Liqun; Klepacki, Dorota; Mankin, Alexander; Yonath, Ada (National Academy of Sciences, 2010)
      Crystallographic analysis revealed that the 17-member polyketide antibiotic lankacidin produced by Streptomyces rochei, binds at the peptidyl transferase center of the ubacterial large ribosomal subunit. Biochemical and ...

    • Structure of the Francisella tularensis enoyl-acyl carrier protein reductase (FabI) in complex with NAD plus and triclosan 

      Mehboob, Shahila; Truong, Kent; Santarsiero, Bernard D.; Johnson, Michael E. (International Union of Crystallography, 2010-11)
      Enoyl-acyl carrier protein reductase (FabI) catalyzes the last rate-limiting step in the elongation cycle of the fatty-acid biosynthesis pathway and has been validated as a potential antimicrobial drug target in Francisella ...

    • Thermoregulation of Capsule Production by Streptococcus pyogenes 

      Kang, Song Ok; Wright, Jordan O.; Tesorero, Rafael A.; Lee, Hyunwoo; Beall, Bernard; Cho, Kyu Hong (Public Library of Science, 2012-05)
      The capsule of Streptococcus pyogenes serves as an adhesin as well as an anti-phagocytic factor by binding to CD44 on keratinocytes of the pharyngeal mucosa and the skin, the main entry sites of the pathogen. We discovered ...