Browsing Publications - Pharmaceutical Biotechnology by Title
Now showing items 13-18 of 18
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Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI).
(Elsevier Inc., 2015-03-15)Francisella tularensis, the causative agent of tularemia, presents a significant biological threat and is a Category A priority pathogen due to its potential for weaponization. The bacterial FASII pathway is a viable ... -
Structure of dihydroorotase from Bacillus anthracis at 2.6 A resolution
(International Union of Crystallography, 2010-11)Dihydroorotase (EC 3.5.2.3) catalyzes the reversible cyclization of N-carbamoyl-l-aspartate to l-dihydroorotate in the third step of the pyrimidine-biosynthesis pathway in Bacillus anthracis. A comparison is made between ... -
Structure of dihydroorotase from Bacillus anthracis at 2.6 A resolution
(International Union of Crystallography, 2010-11)Dihydroorotase (EC 3.5.2.3) catalyzes the reversible cyclization of N-carbamoyl-l-aspartate to l-dihydroorotate in the third step of the pyrimidine-biosynthesis pathway in Bacillus anthracis. A comparison is made between ... -
The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
(National Academy of Sciences, 2010)Crystallographic analysis revealed that the 17-member polyketide antibiotic lankacidin produced by Streptomyces rochei, binds at the peptidyl transferase center of the ubacterial large ribosomal subunit. Biochemical and ... -
Structure of the Francisella tularensis enoyl-acyl carrier protein reductase (FabI) in complex with NAD plus and triclosan
(International Union of Crystallography, 2010-11)Enoyl-acyl carrier protein reductase (FabI) catalyzes the last rate-limiting step in the elongation cycle of the fatty-acid biosynthesis pathway and has been validated as a potential antimicrobial drug target in Francisella ... -
Thermoregulation of Capsule Production by Streptococcus pyogenes
(Public Library of Science, 2012-05)The capsule of Streptococcus pyogenes serves as an adhesin as well as an anti-phagocytic factor by binding to CD44 on keratinocytes of the pharyngeal mucosa and the skin, the main entry sites of the pathogen. We discovered ...