Now showing items 1-6 of 6
MicroRNAs Implicated in Dysregulation of Gene Expression Following Human Lung Transplantation
Background: Lung transplantation remains the only viable treatment option for the majority of patients with advanced lung diseases. However, 5-year post-transplant survival rates remain low primarily secondary to chronic ...
Bioinformatic resources of microRNA sequences, gene targets, and genetic variation
(Frontiers Research Foundation, 2012)
Variation in quantitative gene expression has been observed in natural populations and associated with various complex traits/phenotypes such as risks for common diseases and drug response. MicroRNAs (miRNAs), a family ...
Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis
(BioMed Central, 2013-06-07)
Background: The Fra-1/AP-1 transcription factor regulates the expression of genes controlling various processes including migration, invasion, and survival as well as extracellular remodeling. We recently demonstrated ...
Integrating microRNAs into a system biology approach to acute lung injury
Acute lung injury (ALI), including the ventilator-induced lung injury (VILI) and the more severe acute respiratory distress syndrome (ARDS), are common and complex inflammatory lung diseases potentially affected by various ...
Linkage of Type I Interferon Activity and TNF-Alpha Levels in Serum with Sarcoidosis Manifestations and Ancestry
(Public Library of Science, 2011-12-14)
Background: Both type I interferon (IFN), also known as IFN-a and tumor necrosis factor alpha (TNF-a) have been implicated in the pathogenesis of sarcoidosis. We investigated serum levels of these cytokines in a large ...
Pharmacogenomic Discovery Delineating the Genetic Basis of Drug Response
(Springer Verlag, 2013-09)
Personalized medicine has the promise to tailor medical care based on the patient’s genetic make-up and clinical variables such as gender, race and exposure to environmental stimuli. Recent progress in pharmacogenetic and ...