Browsing Publications - Pediatrics by Title
Now showing items 13-32 of 55
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Executive Functioning in Children and Adolescents With Perinatal HIV Infection.
(Lippincott, Williams & Wilkins, 2015-09)Background: Perinatal HIV (PHIV) infection may place youth at risk for impairments in executive functioning (EF). We examined associations of EF with HIV infection, disease severity and other factors among youth with PHIV ... -
Experimental Induction of Type 2 Diabetes in Aging-Accelerated Mice Triggered Alzheimer-Like Pathology and Memory Deficits.
(IOS Press, 2013-10)Alzheimer’s disease (AD) is an age-dependent neurodegenerative disease constituting ~95% of late-onset non-familial/sporadic AD (sAD), and only ~5% accounting for early-onset familial AD (fAD). Availability of a pertinent ... -
Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis
(BioMed Central, 2013-06-07)Background: The Fra-1/AP-1 transcription factor regulates the expression of genes controlling various processes including migration, invasion, and survival as well as extracellular remodeling. We recently demonstrated ... -
Fra-1/AP-1 Transcription Factor Negatively Regulates Pulmonary Fibrosis In Vivo
(Public Library of Science, 2012-07)The Fra-1/AP-1 transcription factor plays a key role in tumor epithelial cell progression; however, its role in pathogenic lung fibrosis remains unclear. In the present study, using a genetic approach (Fra-1 deficient ... -
Gender differences in the association of insulin resistance and high-sensitivity c-reactive protein in obese adolescents
(BioMed Central, 2014)Background: Low-grade vascular inflammation is believed to initiate early atherosclerotic process by inducing insulin resistance (IR), with significant gender differences in adults. We evaluated the relationship between ... -
Genetic Associations in the Vitamin D Receptor and Colorectal Cancer in African Americans and Caucasians
(Public Library of Science, 2011-10-27)Low vitamin D levels are associated with an increased incidence of colorectal cancer (CRC) and higher mortality from the disease. In the US, African Americans (AAs) have the highest CRC incidence and mortality and the ... -
GRIM-1, a Novel Growth Suppressor, Inhibits rRNA Maturation by Suppressing Small Nucleolar RNAs
(Public Library of Science, 2011-09)We have recently isolated novel IFN-inducible gene, Gene associated with Retinoid-Interferon-induced Mortality-1 (GRIM-1), using a genetic technique. Moderate ectopic expression of GRIM-1 caused growth inhibition and ... -
Hematological Abnormalities in Neonatal Necrotizing Enterocolitis
(Informa Healthcare, 2012-10)Objective: Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants born prior to 32 weeks gestation or with a birth weight less than 1500 grams. In this article, we review hematological ... -
Heterozygous Mutations in DNA Repair Genes and Hereditary Breast Cancer: A Question of Power
(Public Library of Science, 2012-09) -
Histone lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion and DNA methylation of human neuroblastoma cells
(Lippincott, Williams & Wilkins, 2013-06)Background: Neuroblastoma (NB), a childhood neoplasm arising from neural crest cells, is characterized by a diversity of clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. In ... -
Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells.
(Nature Publishing Group, 2015-07-13)There is growing evidence that microRNAs play important roles in cellular responses to hypoxia and in pulmonary hypertensive vascular remodeling, but the exact molecular mechanisms involved are not fully elucidated. In ... -
Hypoxia modulates the expression of leucine zipper-positive MYPT1 and its interaction with protein kinase G and Rho kinases in pulmonary arterial smooth muscle cells
(Medknow Publications, 2011-10)We have shown previously that acute hypoxia downregulates protein kinase G (PKG) expression and activity in ovine fetal pulmonary vessels and pulmonary arterial smooth muscle cells (SMC). Here, we report that acute hypoxia ... -
Hypoxia modulates the expression of leucine zipper-positive MYPT1 and its interaction with protein kinase G and Rho kinases in pulmonary arterial smooth muscle cells
(Medknow Publications, 2011)We have shown previously that acute hypoxia downregulates protein kinase G (PKG) expression and activity in ovine fetal pulmonary vessels and pulmonary arterial smooth muscle cells (SMC). Here, we report that acute hypoxia ... -
Hypoxia modulates the expression of leucine zipper-positive MYPT1 and its interaction with protein kinase G and Rho kinases in pulmonary arterial smooth muscle cells.
(Medknow Publications, 2011-10)We have shown previously that acute hypoxia downregulates protein kinase G (PKG) expression and activity in ovine fetal pulmonary vessels and pulmonary arterial smooth muscle cells (SMC). Here, we report that acute hypoxia ... -
In utero and postnatal exposure to antiretrovirals among hiv-exposed but uninfected children in the United States
(Mary Ann Liebert, 2010-01-18)OBJECTIVE Antiretroviral (ARV) drugs are routinely provided to HIV-infected pregnant women to prevent HIV mother-to-child transmission. Although ARV use has significantly reduced mother-to-child transmission to <2% in the ... -
Initial Steps for Quality Improvement of Obesity Care Across Divisions at a Tertiary Care Pediatric Hospital
(MDPI, 2014-09)Abstract: Background: Pediatric subspecialists can participate in the care of obese children. Objective: To describe steps to help subspecialty providers initiate quality improvement efforts in obesity care. Methods: An ... -
Initial steps for quality improvement of obesity care across divisions at a tertiary care pediatric hospital.
(MDPI, 2014-09-17)BACKGROUND: Pediatric subspecialists can participate in the care of obese children. OBJECTIVE: To describe steps to help subspecialty providers initiate quality improvement efforts in obesity care. METHODS: An anonymous ... -
Integrating microRNAs into a system biology approach to acute lung injury
(Elsevier, 2011-04)Acute lung injury (ALI), including the ventilator-induced lung injury (VILI) and the more severe acute respiratory distress syndrome (ARDS), are common and complex inflammatory lung diseases potentially affected by various ... -
Knockdown of von Hippel-Lindau Protein decreases lung cancer cell proliferation and colonization
(Elsevier, 2012-05)Although von Hippel-Lindau protein (pVHL) is known as a tumor suppressor in kidney and other organs, it remains unclear whether pVHL plays a role in lung cancer development. We investigated the role of pVHL in lung cancer ... -
Linkage of Type I Interferon Activity and TNF-Alpha Levels in Serum with Sarcoidosis Manifestations and Ancestry
(Public Library of Science, 2011-12-14)Background: Both type I interferon (IFN), also known as IFN-a and tumor necrosis factor alpha (TNF-a) have been implicated in the pathogenesis of sarcoidosis. We investigated serum levels of these cytokines in a large ...