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Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension
Rationale: Forkhead box M1 (FoxM1) is a transcription factor that promotes cell proliferation by regulating a broad spectrum of genes that participate in cell cycle regulation, such as Cyclin B, CDC25B, and Aurora B Kinase. ...
PAI-1 is a novel component of the miR-17~92 signaling that regulates pulmonary artery smooth muscle cell phenotypes
(American Physiological Society, 2018-08-01)
We have previously reported that miR-17~92 is critically involved in the pathogenesis of pulmonary hypertension (PH). We also identified two novel mR-17/20a direct targets PDLIM5 and PHD2 and elucidated the signaling ...