Now showing items 1-3 of 3
Alpha-Enolase Regulates the Malignant Phenotype of Pulmonary Artery Smooth Muscle Cells via the AMPK-Akt pathway
(Nature Research, 2018-09-21)
The molecular mechanisms underlying the metabolic shift toward increased glycolysis observed in pulmonary artery smooth muscle cells (PASMC) during the pathogenesis of pulmonary arterial hypertension (PAH) are not fully ...
Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension
Rationale: Forkhead box M1 (FoxM1) is a transcription factor that promotes cell proliferation by regulating a broad spectrum of genes that participate in cell cycle regulation, such as Cyclin B, CDC25B, and Aurora B Kinase. ...
PAI-1 is a novel component of the miR-17~92 signaling that regulates pulmonary artery smooth muscle cell phenotypes
(American Physiological Society, 2018-08-01)
We have previously reported that miR-17~92 is critically involved in the pathogenesis of pulmonary hypertension (PH). We also identified two novel mR-17/20a direct targets PDLIM5 and PHD2 and elucidated the signaling ...