Now showing items 1-10 of 10
Targeted Deletion of Jun/AP-1 in Alveolar Epithelial Cells Causes Progressive Emphysema and Worsens Cigarette Smoke-Induced Lung Inflammation
The c-Jun/AP-1 transcriptional factor is known to regulate cell proliferation, apoptosis, and inflammatory responses; however its role in lung pathogenesis is largely unknown. Here we report that the declined expression ...
Development of Optimal Kids Insulin Dosing System Formulas for Young Children with Type 1 Diabetes Mellitus
(Mary Ann Liebert, 2012-05)
Objective: This study was designed to develop predictive formulas for precise insulin dosing in young children with type 1 diabetes (T1DM). Research Design and Methods: Consecutive 1-year data from a group of 14 young ...
Hematological Abnormalities in Neonatal Necrotizing Enterocolitis
(Informa Healthcare, 2012-10)
Objective: Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants born prior to 32 weeks gestation or with a birth weight less than 1500 grams. In this article, we review hematological ...
Fra-1/AP-1 Transcription Factor Negatively Regulates Pulmonary Fibrosis In Vivo
(Public Library of Science, 2012-07)
The Fra-1/AP-1 transcription factor plays a key role in tumor epithelial cell progression; however, its role in pathogenic lung fibrosis remains unclear. In the present study, using a genetic approach (Fra-1 deficient ...
Parathyroid Hormone Is Associated with Biomarkers of Insulin Resistance and Inflammation, Independent of Vitamin D Status, in Obese Adolescents
(Mary Ann Liebert, 2012-12)
Background: 25-Hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) have been shown to correlate with several markers of metabolic syndrome in adult populations. We evaluated the relationship between circulating intact ...
Bioinformatic resources of microRNA sequences, gene targets, and genetic variation
(Frontiers Research Foundation, 2012)
Variation in quantitative gene expression has been observed in natural populations and associated with various complex traits/phenotypes such as risks for common diseases and drug response. MicroRNAs (miRNAs), a family ...
Heterozygous Mutations in DNA Repair Genes and Hereditary Breast Cancer: A Question of Power
(Public Library of Science, 2012-09)
Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles
(BioMed Central, 2012-04)
This report is based on the Federation of American Societies for Experimental Biology’s symposium, “Engaging basic Scientists in Translational Research: Identifying Opportunities, Overcoming Obstacles,” held in Chevy ...
cAMP-dependent protein kinase is essential for hypoxia-mediated epithelial-mesenchymal transition, migration, and invasion in lung cancer cells
Lung cancer is the leading cause of cancer-related death worldwide. Hypoxia is known to increase cancer cell migration and invasion. We have previously reported that hypoxia induces epithelial-mesenchymal transition (EMT) ...
Knockdown of von Hippel-Lindau Protein decreases lung cancer cell proliferation and colonization
Although von Hippel-Lindau protein (pVHL) is known as a tumor suppressor in kidney and other organs, it remains unclear whether pVHL plays a role in lung cancer development. We investigated the role of pVHL in lung cancer ...