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Enhanced Ca2+-sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension
(American Heart Association, 2012-08)
Rationale: A rise in cytosolic Ca2+ concentration ([Ca2+]cyt) in pulmonary arterial smooth muscle cells (PASMC) is an important stimulus for pulmonary vasoconstriction and vascular remodeling. Increased resting [Ca2+]cyt ...