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Decreased Warfarin Clearance with the CYP2C9 R150H (*8) Polymorphism
(Nature Publishing Group, 2012-04)
The cytochrome P450 (CYP) 2C9 R150H (*8) allele occurs commonly in African Americans and is associated with lower warfarin dose requirements. We examined whether the CYP2C9*8 allele impacts warfarin clearance through a ...
Pathway analysis of genome-wide data improves warfarin dose prediction
(BioMed Central, 2013-05)
Background: Many genome-wide association studies focus on associating single loci with target phenotypes. However, in the setting of rare variation, accumulating sufficient samples to assess these associations can ...