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Decreased Warfarin Clearance with the CYP2C9 R150H (*8) Polymorphism
(Nature Publishing Group, 2012-04)
The cytochrome P450 (CYP) 2C9 R150H (*8) allele occurs commonly in African Americans and is associated with lower warfarin dose requirements. We examined whether the CYP2C9*8 allele impacts warfarin clearance through a ...
The Role of Pharmacogenomics in the Management of Traditional and Novel Oral Anticoagulants
(IOS Press, 2011-12)
Warfarin is the most commonly prescribed oral anticoagulant. However, it remains a difficult drug to manage mostly because of its narrow therapeutic index and wide inter-patient variability in anticoagulant effects. Over ...