Show simple item record

dc.contributor.authorBenford, Marnita L.
dc.contributor.authorVanCleave, Tiva T.
dc.contributor.authorLavender, Nicole A.
dc.contributor.authorKittles, Rick A.
dc.contributor.authorKidd, LaCreis R.
dc.date.accessioned2011-05-12T02:41:31Z
dc.date.available2011-05-12T02:41:31Z
dc.date.issued2010-06-28
dc.identifier.bibliographicCitationBenford, M. L., VanCleave, T. T., Lavender, N. A., Kittles, R. A., & Kidd, L. R. 2010. 8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control study. BMC Cancer, 10. DOI: 10.1186/1471-2407-10-334en
dc.identifier.issn1471-2407
dc.identifier.otherDOI: 10.1186/1471-2407-10-334
dc.identifier.urihttp://hdl.handle.net/10027/7621
dc.descriptionThe original source for this publication is at BioMed Central; DOI: 10.1186/1471-2407-10-334. © 2010 Benford et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.description.abstractBackground: Human chromosome 8q24 has been implicated in prostate tumorigenesis. Methods: Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR). Results: Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk of developing PCA for our test group. These findings were validated using multifactor dimensionality reduction (MDR) and permutation testing (p = 0.038). The remaining 8q24 targets were not significantly related to PCA outcomes. Conclusions: Although compelling evidence suggests that the 8q24 rs16901979 locus may serve as an effective PCA predictor, our findings require additional evaluation in larger studies.en
dc.description.sponsorshipThis study was supported in part by the NIH R03 CA128028, the James Graham Brown Cancer Center, and the Bucks for Brains "Our Highest Potential" in Cancer Research Endowment.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.subjectchromosome 8Q24en
dc.subjectprostate canceren
dc.title8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control studyen
dc.typeArticleen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record