Logo for the University of Illinois at Chicago
    • Login
    View Item 
    •   INDIGO Home
    • Medicine, College of
    • College of Medicine at Chicago
    • Medicine, Department of
    • Publications - Medicine
    • View Item
    •   INDIGO Home
    • Medicine, College of
    • College of Medicine at Chicago
    • Medicine, Department of
    • Publications - Medicine
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The insulin immunoassay after 50 years: a reassessment

    Thumbnail
    View/Open
    52.3.blumenthal.pdf (325.6Kb)
    Date
    2009
    Author
    Blumenthal, Stanley
    Publisher
    University of Chicago Press
    Metadata
    Show full item record
    Abstract
    In 1960 Berson and Yalow published a method for the radioimmunoassay (RIA) of plasma insulin based on the concept that the extent to which unlabeled insulin displaces labeled insulin from anti-insulin antibody is proportional to the concentration of unlabeled insulin. The RIA for insulin has greatly increased knowledge of the physiology of glucose homeostasis and of the diverse causes of diabetes mellitus. Beyond this, the insight on which the RIA—or,more broadly, the competitive protein-binding assay—is based has provided the means to measure nanomolar or picomolar concentrations of a vast array of compounds in plasma and tissues. Directly or indirectly, the RIA has profoundly affected every branch of medicine.This essay reviews the ideas that were current in the medical research community when Berson and Yalow began their work and the observations and reasoning process that led them to their seminal discovery.
    Subject
    radioimmunoassay
    plasma insulin
    Type
    Article
    Date available in INDIGO
    2011-05-25T18:46:09Z
    URI
    http://hdl.handle.net/10027/7650
    Collections
    • Publications - Medicine

    DSpace software copyright © 2002-2015  DuraSpace
    Contact Us | Send Feedback | Privacy Statement
    Theme by 
    Atmire NV

    Browse

    All of INDIGOCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2015  DuraSpace
    Contact Us | Send Feedback | Privacy Statement
    Theme by 
    Atmire NV