Now showing items 1-4 of 4
Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4
(Elsevier (Cell Press), 2016-07-12)
The molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in human embryonic stem cells (hESCs) are not fully understood. We found that high levels of glutamine metabolism are essential to ...
Bioenergetic shifts during transitions between stem cell states
(Pulmonary Circulation, 2014-09-01)
Two defining characteristics of stem cells are their multilineage differentiation potential (multipotency or pluripotency) and their capacity for self-renewal. Growth factors are well-established regulators of stem cell ...
SLIT3–ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo
(Journal of Molecular and Cellular Cardiology, 2013-11-01)
Successful implantation and long-term survival of engineered tissue grafts hinges on adequate vascularization of the implant. Endothelial cells are essential for patterning vascular structures, but they require supportive ...
Mitochondrial Respiration Regulates Adipogenic Differentiation of Human Mesenchymal Stem Cells
(Public Library of Science, 2013)
Human mesenchymal stem cells (MSCs) are adult multipotent stem cells which can be isolated from bone marrow, adipose tissue as well as other tissues and have the capacity to differentiate into a variety of mesenchymal cell ...