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dc.contributor.authorCao, Dingcai
dc.contributor.authorZele, Andrew J.
dc.contributor.authorPokorny, Joel
dc.contributor.authorLee, David Y.
dc.contributor.authorMessner, Leonard V.
dc.contributor.authorDiehl, Christopher
dc.contributor.authorKsiazek, Susan
dc.date.accessioned2012-06-25T04:30:00Z
dc.date.available2012-06-25T04:30:00Z
dc.date.issued2011-11
dc.identifier.bibliographicCitationCao, D., Zele, A. J., Pokorny, J., Lee, D. Y., Messner, L. V., Diehl, C., & Ksiazek, S. 2011. Functional Loss in the Magnocellular and Parvocellular Pathways in Patients with Optic Neuritis. Clinical Pharmacology and Therapeutics. 2011 Nov 17;52(12):8900-7. Print 2011. doi: 10.1167/iovs.11-7644en
dc.identifier.issn0146-0404
dc.identifier.otherdoi: 10.1167/iovs.11-7644
dc.identifier.urihttp://hdl.handle.net/10027/8367
dc.descriptionPost print version of article may differ from published version. The definitive version is available through Association for Research in Vision and Ophthalmology at doi: 10.1167/iovs.11-7644en
dc.description.abstractPurpose: To evaluate contrast threshold and contrast gain in patients with optic neuritis under conditions designed to favor mediation by either the inferred Magnocellular (MC-) or Parvocellular (PC-) pathway. Methods: Achromatic and chromatic contrast discrimination was measured in 11 patients with unilateral or bilateral optic neuritis and 18 age-matched controls with normal vision, using achromatic steady-pedestal and pulsed-pedestal paradigms to bias performance toward the MC- or PC- pathway respectively. Additionally, L-M chromatic discrimination at equiluminance was evaluated using the steady-pedestal paradigm. . A physiologically plausible model could describe the data with parameters accounting for contrast gain and contrast sensitivity in the inferred MC- or PC- pathway. The fitted parameters from the affected eye by optic neuritis were compared with those from the normal eyes using Generalized Estimation Equation (GEE) models that can account for within-subject correlations. Results: Compared with normal eyes, the affected eyes had significantly higher saturation parameters when measured with both the achromatic pulsed-pedestal paradigm [GEE: β(se) = 0.35(0.06), p < 0.001] and the chromatic discrimination paradigm [β(se) = 0.18(0.08), p = 0.015], suggesting contrast gain in the inferred PCpathway is reduced; the affected eyes also had reduced absolute sensitivity in the inferred MC-pathway measured with the achromatic steady-pedestal paradigm [β(se) = 0.12 (0.04), p = 0.005]. Conclusion: Optic neuritis produced large sensitivity loss mediated by the MCpathway and contrast gain losses in the inferred PC- pathway. A clinical framework is presented for interpreting contrast sensitivity and gain loss to chromatic and achromatic stimuli in terms of retinal and post-retinogeniculate loci contributions to detection and discrimination.en
dc.description.sponsorshipNational Eye Institute grants R01EY019651 (D. Cao) and by Australia Research Council Discovery Projects DP1096354 (AJZ) supported this work.en
dc.language.isoen_USen
dc.publisherAssociation for Research in Vision and Ophthalmologyen
dc.titleFunctional Loss in the Magnocellular and Parvocellular Pathways in Patients with Optic Neuritisen
dc.typeArticleen


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