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dc.contributor.authorAl-Alem, Umaima
dc.contributor.authorGann, Peter H.
dc.contributor.authorDahl, Jeffrey
dc.contributor.authorBreemen, Richard B. van
dc.contributor.authorMistry, Vilas
dc.contributor.authorLam, Patricia M.W.
dc.contributor.authorEvans, Mark D.
dc.contributor.authorHorn, Linda Van
dc.contributor.authorWright, Margaret E.
dc.date.accessioned2012-08-14T18:34:33Z
dc.date.available2012-08-14T18:34:33Z
dc.date.issued2012
dc.identifier.bibliographicCitationAl-Alem, U., Gann, P. H., Dahl, J., van Breemen, R. B., Mistry, V., Lam, P. M., Evans, M. D., Van, H. L., & Wright, M. E. 2011. Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenopausal women. Genes and Nutrition. Apr;7(2):191-5. DOI: 10.1007/s12263-011-0257-3en
dc.identifier.issn1555-8932
dc.identifier.otherDOI: 10.1007/s12263-011-0257-3
dc.identifier.urihttp://hdl.handle.net/10027/8449
dc.description© 2012 by Springer Verlag, Genes and Nutrition The original publication is available at www.springerlink.com DOI: 10.1007/s12263-011-0257-3en
dc.description.abstractFunctional polymorphisms in endogenous antioxidant defense genes including manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX-1) have been linked with risk of cancer at multiple sites. Although it is presumed that these germline variants impact disease risk by altering the host’s ability to detoxify mutagenic reactive oxygen species, very few studies have directly examined this hypothesis. Concentrations of 8-isoprostane F2α (8-iso-PGF2α) and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxoxdG) – sensitive indicators of lipid peroxidation and DNA oxidation, respectively – were measured in 24-hour urine samples obtained from 93 healthy, premenopausal women participating in a dietary intervention trial. In addition, DNA was extracted from blood for genotyping of MnSOD Val16Ala, CAT -262 C>T, and GPX1 Pro198Leu genotypes by Taqman assay. Although geometric mean concentrations of 8-iso-PGF2α and 8-oxoxdG varied across several study characteristics including race, education level, body mass index, and serum antioxidant levels, there was little evidence that these biomarkers differed across any of the examined genotypes. In summary, functional polymorphisms in endogenous antioxidant defense genes do not appear to be strongly associated with systemic oxidative stress levels in young, healthy women.en
dc.description.sponsorshipFunding was provided by a pilot grant from the University of Illinois at Chicago Cancer Center.en
dc.language.isoen_USen
dc.publisherSpringer Verlagen
dc.titleAssociations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenoupausal womenen
dc.typeArticleen


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