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dc.contributor.authorVarady, Krista A.
dc.contributor.authorBhutani, Surabhi
dc.contributor.authorKlempel, Monica C.
dc.contributor.authorLamarche, Benoît
dc.date.accessioned2012-08-17T19:53:00Z
dc.date.available2012-08-17T19:53:00Z
dc.date.issued2011-02
dc.identifier.bibliographicCitationVarady, K. A., Bhutani, S., Klempel, M. C., & Lamarche, B. 2011. Improvements in LDL particle size and distribution by short-term alternate day modified fasting in obese adults. British Journal of Nutrition , 105(4):580-3. DOI: 10.1017/S0007114510003788en
dc.identifier.issn0007-1145
dc.identifier.otherDOI: 10.1017/S0007114510003788
dc.identifier.urihttp://hdl.handle.net/10027/8543
dc.description© Varady e.t al. 2010. The original version is available through Cambridge University Press at DOI: 10.1017/S0007114510003788en
dc.description.abstractAlternate day modified fasting (ADMF) beneficially modulates several indicators of CHD risk, but its effects on LDL particle size have never been tested. Accordingly, we examined the effects of ADMF on LDL particle size and distribution in obese adults. Sixteen obese subjects participated in a 10-week trial with three consecutive phases: (1) 2-week control phase; (2) 4-week ADMF controlled feeding phase; (3) 4-week ADMF self-selected feeding phase. After 8 weeks of diet, body weight and waist circumference were reduced (P,0·05) by 5·6 (SEM 0·9) kg and 4·0 (SEM 0·9) cm, respectively. LDL-cholesterol and TAG concentrations decreased (P,0·05) by 25 (SEM 10)% and 32 (SEM 6)%, respectively. Peak LDL particle size increased (P,0·05) from 266 (SEM 1) to 268 (SEM 1)Ȧ. Additionally, the proportion of small LDL particles decreased (P,0·05) from 13 (SEM 2)% to 9 (SEM 3)%, while the proportion of large LDL particles increased (P,0·05) from 68 (SEM 4)% to 76 (SEM 4)% post-treatment. These findings suggest that ADMF is an effective diet strategy for increasing LDL particle size and decreasing the proportion of small, dense LDL particles in obese adults.en
dc.language.isoen_USen
dc.publisherCambridge University Pressen
dc.subjectAlternate day fastingen
dc.subjectLDL particle sizeen
dc.subjectCholesterolen
dc.subjectCHDen
dc.subjectObese adultsen
dc.titleImprovements in LDL particle size and distribution by short-term alternate day modified fasting in obese adultsen
dc.typeArticleen


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