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    Self-assembling process of flash nanoprecipitation in a multi-inlet vortex mixer to produce drug-loaded polymeric nanoparticles

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    Date
    2011-09
    Author
    Shen, Hao
    Hong, Seungpyo
    Prud'homme, Robert
    Liu, Ying
    Publisher
    Springer Verlag
    Metadata
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    Abstract
    We present an experimental study of self-assembled polymeric nanoparticles in the process of flash nanoprecipitation using a multi-inlet vortex mixer (MIVM). beta-Carotene and polyethyleneimine (PEI) are used as a model drug and a macromolecule, respectively, and encapsulated in diblock copolymers. Flow patterns in the MIVM are microscopically visualized by mixing iron nitrate (Fe(NO(3))(3)) and potassium thiocyanate (KSCN) to precipitate Fe(SCN) (x) ((3-x)+) . Effects of physical parameters, including Reynolds number, supersaturation rate, interaction force, and drug-loading rate, on size distribution of the nanoparticle suspensions are investigated. It is critical for the nanoprecipitation process to have a short mixing time, so that the solvent replacement starts homogeneously in the reactor. The properties of the nanoparticles depend on the competitive kinetics of polymer aggregation and organic solute nucleation and growth. We report the existence of a threshold Reynolds number over which nanoparticle sizes become independent of mixing. A similar value of the threshold Reynolds number is confirmed by independent measurements of particle size, flow-pattern visualization, and our previous numerical simulation along with experimental study of competitive reactions in the MIVM.
    Subject
    cancer
    nanoparticles
    Type
    Article
    Date available in INDIGO
    2012-08-18T03:23:18Z
    URI
    http://hdl.handle.net/10027/8552
    Collections
    • Publications - Chemical Engineering
    • Publications - Biopharmaceutical Sciences

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