Browsing Publications - Medicinal Chemistry and Pharmacognosy by Subject "Splicing inhibitor"
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Biosynthetic engineering and fermentation media development leads to gram-scale production of spliceostatin natural products in Burkholderia sp. (Elsevier, 2016-01)A key challenge in natural products drug discovery is compound supply. Hundreds of grams of purified material are needed to advance a natural product lead through preclinical development. Spliceostatins are polyketide-nonribosomal ...