Browsing Publications - Medicinal Chemistry and Pharmacognosy by Subject "sGC/NO/cGMP"
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Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia. (BioMed Central, 2015-10-19)BACKGROUND: Synaptic dysfunction is a key event in pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD) where synapse loss pathologically correlates with cognitive decline and dementia. Although ...