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Function of conserved transcription factors in the C. elegans somatic gonad and pharynx
Mammalian EGR-family genes and T-box family genes are broadly expressed and mutants result in a variety of defects and diseases (O'Donovan et al., 1999). To aid in our understanding of how these transcription factor ...
Leveraging Genomic and Microarray Data to Find Direct Targets of the C. elegans Transcription Factor TBX-2
Four independent methods were used to produce a data set enriched for direct targets of C. elegans TBX-2. A microarray experiment comparing wild-type and mutant tbx-2 embryos was analyzed, resulting in a set of ...
SUMOylation is Required for Function of the Caenorhabditis elegans T-box Transcription Factor, TBX-2
T-box proteins are important dose-dependent developmental regulators of multicellular organisms, but little information exists regarding regulation of T-box factors in vivo. We are studying C. elegans TBX-2 to elucidate ...