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Structural and Functional Studies of Bacillus anthracis Enzymes in de novo Purine Synthesis
The de novo purine biosynthesis is an essential life sustaining process in many organisms, including bacterial pathogens. My work investigates the structural and functional properties of enzymes from this pathway in Bacillus ...
Biophysical Studies of Enzymes in the Purine Biosynthetic Pathway of Pathogens for Antibiotic Development
The de novo purine biosynthetic pathway is essential for most organisms. Structure based drug design of critical enzymes of this pathway, such as PurE and PurC, could lead to an effective antibiotic by gaining molecular ...
Differences in the purification and solution properties of PurC gene products from Streptococcus pneumoniae and Bacillus anthracis
(Elsevier Inc., 2015-10)
4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide synthetase (PurC) is a key enzyme in the de novo purine biosynthetic pathway of bacteria and an ideal target pathway for the discovery of antimicrobials. Bacillus ...