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dc.contributor.advisorPhillips, Shane A.en_US
dc.contributor.authorFranklin, Nina C.en_US
dc.date.accessioned2012-12-13T21:59:17Z
dc.date.available2012-12-13T21:59:17Z
dc.date.created2012-08en_US
dc.date.issued2012-12-13
dc.date.submitted2012-08en_US
dc.identifier.urihttp://hdl.handle.net/10027/9559
dc.description.abstractSedentary lifestyle is a significant health problem in the United States and a leading cause of preventable death. Low levels of physical activity promote obesity and contribute to other chronic diseases, such as hypertension, type 2 diabetes mellitus, and some forms of cancer. Vascular dysfunction is a key event in the development of atherosclerosis and associated with a sedentary lifestyle in otherwise healthy adults. In addition, vascular dysfunction may be exacerbated in sedentary adults who are obese since increased body fat is associated with elevated levels of pro-atherogenic inflammatory adipokines and cytokines that reduce nitric oxide bioavailability in vascular endothelial cells. A study examining the effects of single and multiple bouts of resistance exercise training on vascular function was carried out in sedentary obese young women. A total of 10 women completed the entire study. Subjects were evaluated at multiple time points before, during, and after participation in an 8-week moderate-intensity resistance exercise training intervention. At each time point subjects underwent a single bout of strenuous weight lifting designed to increase blood pressure. Vascular function was assessed before and after strenuous weight lifting using brachial artery flow-mediated dilation and blood samples were obtained for measurement of circulating adipokine and cytokine levels. Other relevant physical and physiological variables assessed included: fasting lipids and glucose, red and white blood cells, platelets, hemoglobin, and hematocrit, blood pressure, heart rate, anthropometrics, body composition, daily physical activity, functional capacity, muscular strength, and dietary patterns. Brachial artery flow-mediated dilation was impaired in sedentary obese women after a single bout of strenuous weight lifting and an 8-week moderate-intensity resistance exercise training intervention completely reversed this impairment. In addition, resistance exercise training resulted in improvements in waist circumference, body composition, functional capacity, and muscular strength. There were no significant changes in fasting lipids or glucose levels, red or white blood cells, platelets, hemoglobin, or hematocrit, blood pressure, or heart rate as a result of the resistance exercise training intervention. Changes in brachial artery flow-mediated dilation post-acute exertion and after 8 weeks of resistance exercise training were not linked to obesity-related changes in circulating adipokine and cytokine levels.en_US
dc.language.isoenen_US
dc.rightsCopyright 2012 Nina C. Franklinen_US
dc.subjectVascular Dysfunctionen_US
dc.subjectBlood Flowen_US
dc.subjectExerciseen_US
dc.subjectObesityen_US
dc.titleResistance Exercise Training Improves Vascular Function after Acute Exertion in Obese Womenen_US
thesis.degree.departmentPhysical Therapyen_US
thesis.degree.disciplineKinesiology, Nutrition, and Rehabilitationen_US
thesis.degree.grantorUniversity of Illinois at Chicagoen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePhD, Doctor of Philosophyen_US
dc.type.genrethesisen_US
dc.contributor.committeeMemberTate, Charlotte A.en_US
dc.contributor.committeeMemberKoh, Timothy J.en_US
dc.contributor.committeeMemberVarady, Kristaen_US
dc.contributor.committeeMemberPiano, Mariannen_US
dc.type.materialtexten_US


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