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dc.contributor.advisorBongarzone, Ernesto R.en_US
dc.contributor.authorHu, Yuan-Shihen_US
dc.date.accessioned2012-12-13T22:00:09Z
dc.date.available2012-12-13T22:00:09Z
dc.date.created2012-08en_US
dc.date.issued2012-12-13
dc.date.submitted2012-08en_US
dc.identifier.urihttp://hdl.handle.net/10027/9578
dc.description.abstractAlzheimer’s disease (AD) is an aging-linked neurodegenerative disease characterized by memory impairments and cognitive deterioration, and it is associated with a massive loss of neurons in specific brain areas, such as in the hippocampal formation and in the cortex. The pathological hallmarks of the disease include amyloid deposition and neurofibrillary tangles. The familial form of the disease (FAD) is caused by mutations in amyloid precursor protein (APP), presenilin-1 (PS1) or presenilin-2 (PS2). This work suggests that in addition to genetics, environmental factors play an important role in the development and/or progression of the disease. Modulation of environmental factors can promote hippocampal neurogenesis and synaptic plasticity, as well as ameliorates AD pathology. Specifically, we showed that experience of transgenic mice harboring FAD-linked APPswe/PS1ΔE9 in an enriched environment dramatically reduced the levels of oligomeric Aβ and the extent of amyloid deposition in the brains. We also observed a significant reduction in the level of hyperphosphorylated tau concomitantly with the upregulation of the main anterograde motor protein, kinesin-1, in several brain regions of these mice. The molecular pathways underlying the effects of EE on AD pathology and neuroplasticity are not fully understood. In this study, we aimed at investigating the molecular pathways by which environmental enrichment regulates neuroplasticity and tau phosphorylation. We showed that the levels of BDNF and BDNF-associated molecular targets were significantly elevated in the hippocampus following EE, suggesting an increased of BDNF-dependent signaling transductions following EE. In addition, we showed that EE modulated PI3K/Akt/GSK3β signaling pathway in the nontransgenic mice, suggesting that EE induces a reduction in GSK3β activity in an Akt-dependent manner. However, this signaling pathway was not affected in APPswe/PS1ΔE9 mice following EE, suggesting an alternative signaling regulation by EE in FAD mice. Taken together, this work strongly suggests that despite the severe neuropathology, EE can attenuate AD pathology and enhance neuroplasticity in the brains of FAD-linked APPswe/PS1ΔE9 mice. This study further provides several mechanistic explanations for the effects of EE on the AD brains.en_US
dc.language.isoenen_US
dc.rightsCopyright 2012 Yuan-Shih Huen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectEnvironmental Enrichmenten_US
dc.subjectNeural Stem Cellsen_US
dc.subjectBeta-amyloiden_US
dc.subjectTau hyperphosphorylationen_US
dc.subjectBDNFen_US
dc.subjectGSK3βen_US
dc.subjectBrain-derived Neurotrophic Factoren
dc.subjectGlycogen Synthase Kinase 3βen
dc.titleModulation of Alzheimer's Disease Pathology and Neuroplasticity by Environmental Factorsen_US
thesis.degree.departmentAnatomy and Cell Biologyen_US
thesis.degree.disciplineAnatomy and Cell Biologyen_US
thesis.degree.grantorUniversity of Illinois at Chicagoen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePhD, Doctor of Philosophyen_US
dc.type.genrethesisen_US
dc.contributor.committeeMemberLazarov, Orlyen_US
dc.contributor.committeeMemberBrady, Scott T.en_US
dc.contributor.committeeMemberKessler, John A.en_US
dc.contributor.committeeMemberMufson, Elliott J.en_US
dc.type.materialtexten_US


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