Recent Submissions

  • Lysophosphatidic acid (LPA) and its Receptors: Role in Airway Inflammation and Remodeling 

    Zhao, Yutong; Natarajan, Viswanathan (Elsevier, 2013-01)
    Lysophosphatidic acid (LPA), a simple bioactive phospholipid, is present in biological fluids such as plasma and bronchoalveolar lavage (BAL). It appears to have both pro- and anti-inflammatory role in inflammatory lung ...
  • Optimization of isolated perfused/ventilated mouse lung to study hypoxic pulmonary vasoconstriction 

    Yoo, Hae Young; Zeifman, Amy; Ko, Eun A.; Smith, Kimberly A.; Chen, Jiwang; Machado, Roberto F.; Zhao, You-Yang; Minshall, Richard D.; Yuan, Jason X.-J. (Medknow Publications, 2013-04)
    Hypoxic pulmonary vasoconstriction (HPV) is a compensatory physiological mechanism in the lung that optimizes the matching of ventilation to perfusion and thereby maximizes gas exchange. Historically, HPV has been primarily ...
  • Statins as a novel therapeutic strategy in acute lung injury 

    Singla, Sunit; Jacobson, Jeffrey R. (Medknow Publications, 2012-10)
    Acute lung injury (ALI) is a devastating clinical condition associated with pulmonary and systemic inflammation and characterized by incompetence of the pulmonary microvascular barrier culminating in noncardiogenic pulmonary ...
  • Epidemiological and risk analysis of the H7N9 subtype influenza outbreak in China at its early stage 

    Zhuang, QingYe; Wang, SuChun; Wu, MeiLi; Lui, Shuo; Jiang, WenMing; Hou, GuangYu; Li, JinPing; Wang, KaiCheng; Chen, JiMing; Chen, JiWang (SpringerOpen, 2013-09)
    Dozens of human cases infected with H7N9 subtype avian influenza virus (AIV) have been confirmed in China since March, 2013. Distribution data of sexes, ages, professions and regions of the cases were analyzed in this ...
  • Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation 

    Wang, Ting; Wang, Lichun; Moreno-Vinasco, Liliana; Lang, Gabriel D.; Siegler, Jessica H.; Mathew, Biji; Usatyuk, Peter V.; Samet, Jonathan M.; Geyh, Alison S.; Breysse, Patrick N.; Natarajan, Viswanathan; Garcia, Joe G. N. (BioMed Central, 2012-08)
    BACKGROUND: Exposure to particulate matter (PM) is a significant risk factor for increased cardiopulmonary morbidity and mortality. The mechanism of PM-mediated pathophysiology remains unknown. However, PM is proinflammatory ...
  • Statins as a novel therapeutic strategy in acute lung injury 

    Singla, Sunit; Jacobson, Jeffrey R. (Medknow Publications, 2012-10)
    Acute lung injury (ALI) is a devastating clinical condition associated with pulmonary and systemic inflammation and characterized by incompetence of the pulmonary microvascular barrier culminating in noncardiogenic pulmonary ...
  • Peripheral Blood Gene Expression as a Novel Genomic Biomarker in Complicated Sarcoidosis 

    Zhou, Tong; Zhang, Wei; Sweiss, Nadera J.; Chen, Edward S.; Moller, David R.; Knox, Kenneth S.; Ma, Shwu-Fan; Wade, Michael S.; Noth, Imre; Machado, Roberto F.; Garcia, Joe G. N. (Public Library of Science, 2012-09)
    Sarcoidosis, a systemic granulomatous syndrome invariably affecting the lung, typically spontaneously remits but in ,20% of cases progresses with severe lung dysfunction or cardiac and neurologic involvement (complicated ...
  • Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells 

    Yamamura, Aya; Yamamura, Hisao; Zeifman, Amy; Yuan, Jason X-J (Medknow Publications for the Pulmonary Vascular Research Institute (PVRI), 2011-04)
    Intracellular Ca(2+) plays a fundamental role in regulating cell functions in pulmonary arterial smooth muscle cells (PASMCs). A rise in cytosolic Ca(2+) concentration ([Ca(2+)](cyt)) triggers pulmonary vasoconstriction ...
  • An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding 

    Danilov, Sergei M.; Gordon, Kerry; Nesterovitch, Andrew B.; Lu¨ nsdorf, Heinrich; Chen, Zhenlong; Castellon, Maricela; Popova, Isolda A.; Kalinin, Sergey; Mendonca, Emma; Petukhov, Pavel A.; Schwartz, David E.; Minshall, Richard D.; Sturrock, Edward D. (Public Library of Science, 2011-10)
    Background: Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an ...
  • Linkage of Type I Interferon Activity and TNF-Alpha Levels in Serum with Sarcoidosis Manifestations and Ancestry 

    Sweiss, Nadera J.; Zhang, Wei; Franek, Beverly S.; Kariuki, Silvia N.; Moller, David R.; Patterson, Karen C.; Bennett, Peggy; Girijala, Lakshmi R.; Nair, Vaisak; Baughman, Robert P.; Garcia, Joe G. N.; Niewold, Timothy B. (Public Library of Science, 2011-12-14)
    Background: Both type I interferon (IFN), also known as IFN-a and tumor necrosis factor alpha (TNF-a) have been implicated in the pathogenesis of sarcoidosis. We investigated serum levels of these cytokines in a large ...